Liver Glycogen Synthase in Rats with a Glycogen-Storage Disorder. The Role of Glycogen in the Regulation of Glycogen Synthase
نویسندگان
چکیده
منابع مشابه
The activation of glycogen synthase in hepatocytes from rats with a glycogen storage disorder (gsd/gsd).
Rats from the NZR/Mh strain have a genetically-determined deficiency of phosphorylase b kinase activity in the liver which in homozygotes &d/g@ produces a poor activation of glycogen phosphorylase and very high liver glycogen concentrations [I]. They also have low active glycogen synthase activities [l] and previous studies on liver homogenates have shown an inhibition of glycogen synthasephosp...
متن کاملThe Potential Role of Glycogen Synthase Kinase-3β in Neuropathy-Induced Apoptosis in Spinal Cord
Introduction: Glycogen Synthase Kinase-3β (GSK-3β) participates in several signaling pathways and plays a crucial role in neurodegenerative diseases, inflammation, and neuropathic pain. The ratio of phosphorylated GSK-3β over total GSK-3β (p-GSK-3β/t-GSK-3β) is reduced following nerve injury. Apoptosis is a hallmark of many neuronal dysfunctions in the context of neuropathic pain. Thus, this st...
متن کاملAllosteric regulation of glycogen synthase controls glycogen synthesis in muscle.
Glycogen synthase (GS), a key enzyme in glycogen synthesis, is activated by the allosteric stimulator glucose-6-phosphate (G6P) and by dephosphorylation through inactivation of GS kinase-3 with insulin. The relative importance of these two regulatory mechanisms in controlling GS is not established, mainly due to the complex interplay between multiple phosphorylation sites and allosteric effecto...
متن کاملRabbit Liver Glycogen Synthase Kinases
A rabbit liver protein kinase (PCO.,), able to phosphorylate glycogen synthase and phosvitin, has been extensively purified. The enzyme had apparent M, = 170,000-190,000 as judged by gel filtration and was associated with two major polypeptide species, a (Mr = 43,000) and lp (Mr = 25,000). Two other polypeptides, Mr = 38,000 and M, = 35,000, were also detected. Treatment with trypsin led to an...
متن کاملRegulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase.
We report here use of human myoblasts in culture to study the relationships between cellular glycogen concentrations and the activities of glycogen synthase (GS) and AMP-activated protein kinase (AMPK). Incubation of cells for 2 h in the absence of glucose led to a 25% decrease in glycogen content and a significant decrease in the fractional activity of GS. This was accompanied by stimulation o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1980
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1980.tb04697.x